Organophosphates are a class of chemical compounds. They are used as pesticides. They have a pharmacological effect of irreversible
acetylcholinesterase inhibition.
Examples
- Echothiophate (eye drops) : glaucoma treatment
- Sarin (chemical weapon, 'nerve agent')
- Novichok agents (chemical weapon, 'nerve agent')
Symptoms
- Convulsive spasms
- Spastic paralysis
- Bronchorrhea (excessive bronchial secretions)
- Bronchospasm (bronchial constriction)
- SLUDGE
- Salivation (hypersalivation)
- Lacrimation (involuntary)
- Urination (involuntary)
- Defecation (involuntary)
- Gastrointestinal distress (abdominal pain)
- Emesis (vomiting)
- Miosis (pupil constriction)
Complications
- Hypoxia
- Brain damage
- Death 1-10 minutes after exposure
Management
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