α-Synucleinopathies

Disease class: Neurodegenerative diseases

Types 

• Dementia with Lewy bodies
• Multiple system atrophy
• Parkinson disease

 

Pathophysiology  

• A Lewy body is a aggregate of alpha-synuclein protein.
• There is a pathological finding of Lewy bodies in neurons.
• There is a pathological finding of abnormal neurites called Lewy neurites.