Showing posts with label central nervous system disease. Show all posts
Showing posts with label central nervous system disease. Show all posts

Saturday, 3 August 2019

Lacunar stroke

Disease class: Cerebral small vessel diseases
 Disease class: Stroke

Also known as

  • Lacunar stroke 
  • Lacunar infarct (LACI) 
This is a type of ischaemic stroke. It results from the occlusion of small penetrating arteries which provide blood to the brain's deep structures.

 

Etymology

C. Miller Fisher observed "lacunae" (empty spaces) in the deep brain structures after occlusion of 200–800 μm penetrating arteries and connected them with five classic syndromes.

 

Types

  • Pure motor stroke / hemiparesis (occurs in 33–50%)
  • Ataxic hemiparesis (second most frequent)
  • Dysarthria / clumsy hand (sometimes considered a variant of ataxic hemiparesis)
  • Pure sensory stroke
  • Mixed sensorimotor stroke 
  • Silent lacunar infarction. There are no symptoms despite a loss of brain tissue. This often considered to be a non-stroke syndrome because a diagnosis of stroke can be made clinically. However a diagnosis of silent lacunar infarction must be identified by radiological imaging or post-mortem examination.

 

Epidemiology

  • It is estimated that lacunar infarcts account for 25% of all ischaemic strokes.
  • There is an annual incidence of approximately 15 per 100,000 people. 
  • They may be more frequent in men .
  • They may be more frequent in people of African, Mexican, and Hong Kong Chinese descent.

Cerebral small vessel diseases

Types

  • CADASIL
  • cerebral amyloid angiopathy, Familial
  • Fabry disease
  • MELAS syndrome
  • Microscopic polyangiitis
  • stroke, Lacunar

Sunday, 17 March 2019

Stroke

Also known as

  • Apoplexy 
  • CVA
  • Cerebrovascular accident 
  • vascular accident, Brain 

 

Etymology

Stroke stands for "A stroke of apoplexy". αποπληξία(apoplēxía) = a strike from above.

 

Types

 

Risk factors

Causes


Sunday, 3 March 2019

Tourette syndrome

Disease class: Basal ganglia diseases
Disease class: Tic disorders

Also known as

Gilles De La Tourette's syndrome 

 

Differential diagnosis

α-Synucleinopathies

Types 

 

Pathophysiology  

  • A Lewy body is a aggregate of alpha-synuclein protein.
  • There is a pathological finding of Lewy bodies in neurons.
  • There is a pathological finding of abnormal neurites called Lewy neurites.

Dementia with Lewy bodies

Disease class: α-Synucleinopathies
Disease class: Dementia
Disease class: Neurodegenerative diseases 
Disease class: Parkinsonian disorders

Also known as

DLB, Lewy body disease

 

Pathophysiology

DLB is an alpha-synucleinopathy.

 

Epidemiology

  • This is the third most common cause of dementia. 

Differential diagnosis

This is a Parkinson-plus syndrome.

Saturday, 2 March 2019

Parkinson plus syndromes

Also known as

Disorders of multiple system degeneration

 

Definition

These are diseases which cause symptoms and signs that are characteristic of Parkinson disease. They cause additional features which are not seen in Parkinson disease (until the late stages).

Sometimes considered a Parkinson-plus syndrome

 

Pathophysiology

Each disease in this group has a unique pattern of pathological changes, but they all involve degeneration of multiple systems within the central nervous sytem, including the basal ganglia.

Parkinsonian disorders

Tuesday, 12 February 2019

Migraine disorders

Headache homepage

 

Types

  • Migraine with aura
  • Migraine without aura

 

Symptoms

  • Pain
  • Photophobia (aversion to relatively bright light)
  • Aura: an attack of reversible neurological symptoms, including blurred vision, hallucinations, vertigo, numbness, and difficulty in concentrating and speaking.
  • Alice in Wonderland Syndrome: a disturbance of visual perception, affecting body schema, time perception and spatial arrangement perception.

 

Complications

Epilepsy

Disease class: Brain diseases

Types

  • Drug resistant epilepsy
  • epilepsies, Partial
  • epilepsy, Benign neonatal
  • epilepsy, Generalised
  • epilepsy, Post-traumatic
  • epilepsy, Reflex
  • Epileptic syndromes