TDP-43 proteinopathies

Disease class: Neurodegenerative diseases
Disease class: Proteostasis deficiencies

Types

• Amyotrophic lateral sclerosis 
• Frontotemporal lobar degeneration 

 

Pathophysiology 

• TAR DNA-binding protein 43 is a transactive response (TAR) protein. It is also known as TDP-43.
• These diseases share the pathological finding of TDP-43 protein tangles.