P450 enzyme system

Induction usually requires prolonged exposure to the inducing drug, as opposed to P450 inhibitors, where effects are often seen rapidly

Inducers of the P450 system include

• antiepileptics: phenytoin, carbamazepine
• barbiturates: phenobarbitone
• rifampicin
• St John's Wort
• chronic alcohol intake
• griseofulvin
• smoking (affects CYP1A2, reason why smokers require more aminophylline)

Inhibitors of the P450 system include

• antibiotics: ciprofloxacin, erythromycin
• isoniazid
• cimetidine,omeprazole
• amiodarone
• allopurinol
• imidazoles: ketoconazole, fluconazole
• SSRIs: fluoxetine, sertraline
• ritonavir
• sodium valproate
• acute alcohol intake
• quinupristin