The most deadly infectious diseases

Most deaths annually

• #1 Acute respiratory infections
• Coronavirus Disease 2019 (COVID-19)
• Influenza
• Pneumonia
• #2 AIDS (including Tuberculosis + AIDS)
• #3 Diarrhoeal diseases
• Cholera morbus 
• Norovirus gastroenteritis
  
• Rotavirus gastroenteritis
• Adenovirus gastroenteritis
• Astrovirus gastroenteritis
• Shiga-toxin producing Escherichia coli gastroenteritis
• Campylobacteriosis
• Salmonellosis
• Shigellosis
• Clostridioides difficile colitis
  
• Cryptosporidiosis
• Giardiasis
• Amoebiasis
• Blastocystosis
• Cyclosporiasis

• #4 Tuberculosis
• #5 Malaria
• #6 Measles

Highest case fatality rate

• Creutzfeldt–Jakob disease
• African trypanosomiasis
• Visceral leishmaniasis
• Primary amoebic meningoencephalitis
• Rabies
• Balamuthia
• Glanders (sepsis)
• Smallpox (malignant or haemorrhagic type)
• Ebola virus disease (Zaire ebolavirus)
• AIDS / HIV infection
• Anthrax (pulmonary)
• Macanine alphaherpesvirus 1 disease
• Aspergillosis (pulmonary) (opportunistic infection)
• Cryptococcal meningitis (co-infection with HIV)
• Influenza (H5N1)
• Plague (bubonic, pneumonic, septicaemic)
• Tularaemia (pneumonic)
• Marburg virus disease
• Tetanus
• Baylisascariasis
• Hantavirus diseases
• Middle Eastern Respiratory Syndrome
• Eastern equine encephalitis 
• Tuberculosis
  
• Varicella (in newborns)
• Dengue
• Leptospirosis
• Legionellosis
• Meningococcal diseases
• Typhoid fever
• Severe Acute Respiratory Syndrome
• Intestinal capillariasis
• Botulism
• Diphtheria
• Yellow fever
• Pertussis (in infants)
• Angiostrongyliasis
• Coronavirus Disease 2019 (COVID-19)
• Measles 
• Cholera morbus
  
• Brucellosis
• Hepatitis A
• Lassa Fever
• Mumps (encephalitis)
• Venezuelan Equine Encephalitis
• Malaria
• Polio

 

Taxonomy of most deadly diseases 

Viral diseases

• AIDS / HIV
• Coronavirus Disease 2019 (COVID-19)
• Dengue
  
• Eastern equine encephalitis 
• Ebola virus disease
• Hantavirus diseases
  
• Hepatitis A
  
• Influenza
• Lassa Fever
  
• Macanine alphaherpesvirus 1 disease 
• Marburg virus disease
• Measles
• Middle Eastern Respiratory Syndrome
  
• Mumps
  
• Polio
  
• Rabies 
• Severe Acute Respiratory Syndrome
  
• Smallpox
• Varicella 
• Venezuelan Equine Encephalitis
  
• Yellow fever
  

Bacterial diseases

• Anthrax 
• Brucellosis
• Botulism
  
• Cholera morbus 
• Diphtheria
  
• Legionellosis
• Leprosy 
• Leptospirosis
• Meningococcal diseases
  
• Paratyphoid fever 
• Pertussis
  
• Plague
• Tetanus
  
• Tuberculosis
• Tularaemia
  
• Typhoid fever
• Typhus
  

Chromistal diseases

• Blastocystosis
  
• Cryptosporidiosis
  
• Malaria

Protozoal diseases

• African trypanosomiasis
• American trypanosomiasis
• Amoebiasis 
  
• Aspergillosis (pulmonary)
• Balamuthia
  
• Giardiasis 
• Primary amoebic meningoencephalitis
• Visceral leishmaniasis

Fungal diseases

• Aspergillosis (pulmonary)
• Cryptococcal meningitis
  

Animal diseases

• Angiostrongyliasis
• Baylisascariasis
  

Prion diseases

• Creutzfeldt–Jakob disease