Also known as
- C-C Chemokine Receptor Type 2
- C-C Motif Chemokine Receptor 2
- CD192
- Cluster of differentiation 192
- Monocyte Chemoattractant Protein 1 Receptor
- Monocyte Chemotactic Protein 1 Receptor
Biological functions
- Immunity
- Antiviral responses
- Pro-inflammatory responses
Clinical significance
Disorders associated with CCR2 variants include:
Protein profile
- Size (amino acids) = 374
- Molecular mass (Daltons) = 41,915
- Quaternary structure: Interacts with ARRB1. Interacts (via extracellular N-terminal region) with beta-defensin DEFB106A/DEFB106B. Interacts with NUP85; the interaction is required for CCR2 clusters formation on the cell membrane and CCR2 signaling.
- Protein family = Cell surface receptor.
Genetic profile
- Species: Human
- Chromosome: 3
- Band: 3p21.31
- Starts at base pair: 46,353,734
- Ends at base pair: 46,360,928
- Sequence length (base pairs): 7195
See also
- Chemokines
- genecards.org
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