Non-Hodgkin lymphoma

Disease class: Lymphoma

NHL is a large group of diseases which are differentiated from Hodgkin lymphoma. 

Types

B-cell lymphoma (~88% of NHLs)

• Diffuse large B-cell lymphoma (DLBCL) (~31% of NHLs)
• Follicular lymphoma (FL) (~22% of NHLs) 

• Extra-nodal marginal zone B-cell lymphoma (also called MALT lymphoma)
• Mantle cell lymphoma 
• Burkitt lymphoma 
• Primary mediastinal large B-cell lymphoma
• Nodal marginal zone B-cell lymphoma
• Splenic marginal zone lymphoma
• Small lymphocytic lymphoma
• Lymphoplasmacytic lymphoma (Waldenström’s macroglobulinaemia)

 

T-cell lymphoma (~12% of NHLs)

• Peripheral T-cell lymphoma
• Cutaneous (Skin) lymphomas
• Mycosis fungoides 
• Sézary syndrome
• Anaplastic large cell lymphoma
• Angioimmunoblastic lymphoma
• Lymphoblastic lymphomas
• T-cell
• B-cell

 

Epidemiology

• NHL is the 6th most common cancer type in the UK. 
• NHL accounts for 4% of new cancer cases in the UK each year. 
• About 80% of all diagnosed lymphomas are NHL.