Showing posts with label autoimmune disease. Show all posts
Showing posts with label autoimmune disease. Show all posts

Saturday, 21 March 2020

Proctocolitis

Disease class: Colitis
Disease class: Sigmoid diseases

Proctocolitis refers to inflammation spanning from the anus and rectum (proctitis) up a segment of colon (colitis).

 

Causes

 

Related concepts

  • Rectosigmoiditis: inflammation of the rectum, and sigmoid colon
  • Proctosigmoiditis: inflammation of the anus, rectum, and sigmoid colon
  • Distal colitis: inflammation of the entire distal colon up to the splenic flexure (the junction between descending colon and transverse colon)
  • Hemicolitis: inflammation of the entire distal colon including half of the transverse colon
  • Extensive colitis: inflammation of the entire distal colon up to the hepatic flexure (the junction between transverse colon and ascending colon)
  • Pancolitis: inflammation of the entire colon

 

Management

  • Treat underlying causes (see above)
  • See colitis

Friday, 25 October 2019

Toxic megacolon

Disease class: Megacolon

Definition

 

Causes

 

Complications

  • Colonic rupture 
  • Bacteraemia
  • Sepsis
  • Septic shock

 

Investigations

  • Abdominal radiograph (AXR)
  • CT scan of abdomen and pelvis with bowel contrast (if possible)

 

Diagnostic tips

  • Faecal loading can cause small areas of dilatation.
  • It is normal for some segments of bowel to have a relatively large diameter. The "369 rule" refers to the approximate normal diameters of small bowel (up to 3cm), large bowel (up to 6cm), caecum + sigmoid colon (up to 9cm). 
  • If the clinical history and physical examination support a diagnosis of toxic megacolon and the AXR may show abnormal dilation, it is worth discussing the AXR with a specialist colleague.
  • If there is a strong suspicion of toxic megacolon, inform senior colleagues, request an arterial blood gas analysis, request an urgent abdominal radiograph (if not done already) and seek specialist advice immediately.

 

Treatment

Depends on severity and underlying cause

Conservative

  • Watchful waiting

Medical

  • Antibiotic therapy
    • Clostridium difficile eradication therapy (e.g. oral vancomycin)

Surgical

  • Pancolectomy


Megacolon

Disease class: Colonic diseases

Types


A megacolon is a colon with a significantly increased diameter, usually throughout a large continuous segment of bowel.

 

Investigations

  • Abdominal radiograph (AXR)
  • CT scan of abdomen and pelvis with bowel contrast (if possible)

 

Diagnostic tips

  • Faecal loading can cause small areas of dilatation.
  • It is normal for some segments of bowel to have a relatively large diameter. The "369 rule" refers to the approximate normal diameters of small bowel (up to 3cm), large bowel (up to 6cm), caecum + sigmoid colon (up to 9cm).

Saturday, 3 August 2019

Arteritis

Disease class: Vasculitis

Types

 This refers to inflammation of one or more arteries.
 

Fever of unknown origin

Disease class: Fever

Also known as

  • FUO
  • Pyrexia of unknown origin

Fever

Also known as

  • Pyrexia
  • Febrile response

 

Subtypes


Retinal vasculitis

Disease class: Retinal diseases
Disease class: Vasculitis

Aortitis

Disease class: Vasculitis

This refers to inflammation of the aorta.

Sacroiliitis

Disease class: Arthritis

Discitis

Disease class: Spondylitis

Endarteritis

Disease class: Arteritis

Thursday, 13 June 2019